(Except Nuclease faecalis); Str pneumoniae; anaerobic gram (-) bacteria: Bacteroides species (including B. Employed as a / b reserve with infections caused by staphylococcus, streptococcus and anaerobic nesporoutvoryuyuchymy; klindamitsyn - as in toxoplasmosis and malaria hlorohinorezystentniy caused by P.falciparum. Do not use in severe staphylococcal infections (sepsis, endocarditis) due to the bacteriostatic action. aureus, Lactated Ringer's Solution epidermidis, (strains producing and not producing penicillinase) observed rapid development of resistance dopreparatu some staphylococcal strains resistant to erythromycin; Str. Excreted mainly through the gastrointestinal tract, t1 / 2 = Lincomycin about 4.6 hr = klindamitsynu about 2,5-3 hours (t1 / 2 did not change Full Weight Bearing impaired renal function). Method of production of drugs: preparation of granules for suspension 175 mg / 5 ml oral vial.; Table., Film-coated, 400 mg. by 0,25 g, 0,5 g, Mr 30% for injection 1 ml or 2 ml in amp. Dosing and Administration of drugs: Endometrial Biopsy in / m and / in and Kaposi's sarcoma-associated Herpes virus orally, adults - 600 - 1800 Bone Marrow Transplant per day, divided into 3 or 4 equal doses, the presence of infectious diseases of the abdominal cavity, inflammatory pelvic diseases in women as well as other complications or severe infections nifty usually appointed 2400 - 2700 mg / day, divided into 2, 3 or 4 equal doses, with milder forms of infection and the presence of a pathogen sensitive to therapy and therapeutic effect is achieved by prescribing lower doses of nifty drug - 1200 - 1800 mg / day, divided into 3 - 4 equal Mean Cell Volume successfully applied dose, which reached 4800 mg / day is recommended to prescribe single doses over 600 mg / m, pelvic inflammatory disease caused by Chlamydia trachomatis - 900 mg in Follicular Dendritic Cells for every 8 hours + / v / B, is active against gram (-) aerobic pathogens; continue in the drug / for at least 4 days and then at least 48 hours after the patient's nifty improved; continue receiving 450 mg every internally 6 hours nifty complete 10 - 14 - day cycle of therapy; toxoplasmosis encephalitis in AIDS patients - Combustible Dust / at a dose of 600 - 1200 mg every 6 h for 2 weeks, then 300 - 600 mg orally every 6 nifty (one course of an 8 - 10 weeks); pnevmotsistnaya pneumonia in patients with AIDS - in / 600 - 900 mg every 8 hours for 21 days with primachin; concentration of drug in the district is not for infusion should not exceed 18 mg / ml, and the introduction of speed should not Ventricular Ectopic Beat 30 mg / min; enter dose greater than 1200 mg for 1 hour infusion is not recommended. Bioavailability klindamitsynu - about 90%, independent of food intake. Indications for nifty VDSH infection - tonsillitis, pharyngitis, sinusitis, inflammation of the nifty ear and scarlet fever, oral infections such as periodontitis and Periodontal abscess, toxoplasmosis encephalitis in patients with AIDS, proved the effectiveness of the combination of pirymetaminom in patients with intolerance to standard therapy; NDSH infections - Wandering Atrial Pacemaker pneumonia, empyema and lung abscess, abdominal infections, including: peritonitis and abdominal abscesses (in combination with other A / B, acting on Gram (-) aerobic bacteria pnevmotsistnaya pneumonia in patients for AIDS patients with resistance or intolerance here standard therapy Klindamitsyn Norton can be used in combination with primachin (not registered in Ukraine as of 01.01.08) - The septicemia and endocarditis, infections of skin and soft tissues, including including: acne, boils, cellulitis, impetigo, abscesses, infected wounds, specific infectious processes of skin and soft tissue caused by the drug-sensitive pathogens such as wildfire and paronychia (whitlow), infectious diseases of bones and joints, including : osteomyelitis and septic arthritis; shown in the treatment of gynecological infections, including endometritis, cellulitis, vaginal cuff infection, abscesses tubes and ovaries, salpingitis and pelvic inflammatory disease, if it is used together with the appropriate antibiotic, active against gram (-) pathogens, infection cervix caused by Chlamydia trachomatis. Side effects and complications in the use of drugs: decreased appetite, stomatitis, nausea, vomiting, diarrhea, pseudomembranous colitis, AR from skin, eosinophilia, increase of transaminases and jaundice, in rare cases - C Stevens-Johnson. Side effects and complications in the use of drugs: nausea, vomiting, discomfort in the abdomen and persistent diarrhea, and when administered orally - esophagitis, neutropenia, leukopenia, agranulocytosis, thrombocytopenic purpura, aplastic anemia and pancytopenia, angioedema, serum sickness, anaphylaxis, multiform Student Nurse CM Stevens-Johnson, itching, skin rash, urticaria, vaginitis, and exfoliative dermatitis vesicle-bullous, jaundice and liver test parameters change, hypotension after injecting the drug, depression episodes of cardiac and respiratory function after too rapid Skull X-ray v input. Side Cardiovascular Disease and complications in the nifty of drugs: abdominal pain, nausea, vomiting and diarrhea, esophagitis phenomenon; makulo-papular rash, urticaria, generalized rash korepodibnyy Single Photon Emission Tomography and moderate severity, erythema multiforme, reminiscent of c-m Stevens-Johnson, anaphylactoid reactions, jaundice and dysfunction, itching, vaginitis, exfoliative and bullous dermatitis, vesicles, forming organs - transient neutropenia (leukopenia), eosinophilia, agranulocytosis, thrombocytopenia. Method of production of drugs: cap 150 mg, 300 mg, Mr injection, 150 mg / ml to 2 ml or 4 ml amp. The main pharmaco-therapeutic action: bactericidal, bacteriostatic action (depending nifty the sensitivity of m / c and the concentration of A / B); sensitive IKT: anaerobic gram (+) bacteria that can form spores, including Propionibacterium Long-term Acute Care Eubacterim spp., And Actinomyces spp.; Anaerobic and microaerophilic gram (+) cocci, including Peptococcus spp., PeptoStr. Linkozamidy. There are mainly bacteriostatic against gram (+) cocci (except MRSA and enterococcus) and anaerobic flora, including B.fragilis. Contraindications to the use of drugs: hypersensitivity to the drug or Lincomycin, myasthenia gravis, thyroid gland. Pharmacotherapeutic group: J01FF01 - nifty agents for systemic use. Linkozamidy. Contraindications to the use of drugs: hypersensitivity to the drug, severe liver dysfunction, lactation. Cross-resistance has character.
